J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 2786KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 83(9): 896-900, 1982

Report on the annual meeting

MULTIMODAL THERAPY OF RHABDOMYOSARCOMA IN CHILDREN

1) Department of Surgery, National Children's Hospital
2) Department of Urology, National Children's Hospital
3) Department of Otolaryngology, National Children's Hospital
4) Department of Hematology, National Children's Hospital

Kohei Hashizume1), Toshio Nakajo1), Hiroshi Akiyama1), Morihiro Saeki1), Suguru Ogata1), Kazuo Ishida1), Yoshihiro Kakizawa2), Akio Araki3), Keijiro Koga3), Ryo Koide4), Nobuyuki Taguchi4)

Twenty cases of rhabdomyosarcoma in childhood were reviewed. Half of them were male and another half were female. Fourteen of them were under 3 years old. In 12 cases, primary tumor was originated from genito-urinary system. The histologic types were pleomorphic 1, alveolar 3, and embryonal 16.
Before 1975, the treatment was mainly surgical excision without intensive chemotherapy and radiotherapy. Among 8 patients in this group, only one is still alive. From 1975, intensive chemotherapy and high-dose irradiation were introduced. Eight patients out of 12 cases are surviving more than 2 years. The present therapy consists of surgical removal of the tumor if possible, followed by VAC chemotherapy and high-dose (up to 5,000 Rad.) radiation therapy. If the removal of the tumor is impossible, the tumor is biopsied and an intra-arterial catheter is placed. After the regression of the tumor by irradiation (more than 5,000 Rad.) and chemotherapy using the catheter, the tumor is totally extirpated. And the chemotherapy is continued for 2 to 3 years. With this method, pelvic exenteration for rhabdomyosarcoma of the pelvis and amputation for rhabdomyosarcoma of the extremity will be almost unnecessary.

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