J.Jpn. Surg. Soc.. 83(8): 746-759, 1982
Original article
EXPERIMENTAL STUDIES ON GASTRIC MICROCIRCULATION FOLLOWING THERMAL INJURY
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First Department of Surgery, Kyorin University School of Medicine (Director: Prof. Satoru Sohma) Mitsuhisa Ueda |
Rats subjected to a third degree burn, 30% of B.S.A., were studied at times varing from 2 to 72 hours post burn period and compared to the control group. Gastric mucosal blood flow were measured by means of 133-Xenon and hydrogen clearance technique. The microvascular structures were varified by the infusion techniques of Microfil.
In the 2 and 5 hours post burn groups, non-treated and vagotomized rats revealed higher incidence of mucosal lesions and their gastric mucosal blood flow decreased markedly (p＜0.01). Cimetidine treated rats revealed marked protection against gastric mucosal blood flow changes and formation of mucosal lesions. The microvascular structures in these groups showed marked dilatation of true capillaries and collecting venules at the mucosal layer. The opening of the arteriovenous anastomoses and the dilatation of veins were also observed at the submucosal layer. The hemoglobin stained and the silver stained specimens of the gastric mucosa at these hours showed congestion.
Under stressful condition, the gastric microcirculation is disturbed due to the opening of the arteriovenous anastomoses, and the correlation between acute mucosal lesions and impaired gastric microcirculation were noted.
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