J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 2748KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 83(8): 736-745, 1982

Original article

INFLUENCES OF EXTRACORPOREALLY INDUCED TOTAL-BODY HYPERTHERMIA FOR CANCER ON NORMAL ORGANS

First Department of Surgery, Tottori University School of Medicine

Michio Maeta, Shigemasa Koga, Norio Shimizu, Yukio Osaki, Hirotomo Kanayama, Ryuichi Hamazoe, Akio Izumi, Takuo Karino, Toshiaki Yamane

Total-body hyperthermia (TBHT) was induced in patients with terminal malignancy. A total of 31 treatments with duration in 3 to 5 hrs at 41.5 to 42℃ were performed to 11 patients who had unsuccessful chemotherapy. The influences on normal organs were studied and the folowing results were obtained.
Heart rate and cardiac output were increased remarkably during TBHT. Thrombocytopennia and the depression of lymphocyte function were observed in all patients but these changes were reversible except for one patient. He was died of intra-abdominal bleeding due to severe thrombocytopennia after TBHT. Lower leg’s myopathy was found in 7 of 11 patients, but it was preventable with large dose administration of K2HPO4 during TBHT.
The liver and renal functions were hardly damaged by TBHT.
From these results it is concluded that TBHT is carried out with reliable safety on most patients with terminal malignancy excluding those with severe dysfunctions in heart, lung, Liver, kidney or bone marrow.

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