J.Jpn. Surg. Soc.. 83(7): 691-701, 1982

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Original article

EFFECTS OF ANTIPLATELET DRUGS ON PATENCY OF EXPANDED POLYTETRAFLUOROETHYLENE GRAFT

Experimental studies on effects of antiplatelet drugs on patency of expanded polytetrafluoroethylene graft (PTFE) in small arterial replacement was performed on dogs. Platelet aggregation induced by collagen was completely inhibited after four days medication with dipyridamole 100mg/day and aspirin 330mg/day. The same effect was obtained with a half dosis of medication mentioned above.
Based on this finding, a portion of femoral artery was replaced with PTFE, 3mm in diameter and 4cm or 10cm in length, after four days pretreatment followed by continuous administration postoperatively. Patency rate of the graft was 80 per cent in the case of 4cm graft and 40 per cent in the case of 10cm graft at three months, respectively.
Growth of neointima was studied with scanning electron microscope. Neointima originates mainly from host artery at the anastomotic site and covers the inside of the graft, although growth of neointima was limited only within 2 to 3mm of the suture line after three months. However, the graft was patent without lining of neointima on these medication.
It was concluded that antiplatelet drugs are an effective tool to improve the patency rate of PTFE in small arterial replacement.

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