J.Jpn. Surg. Soc.. 83(7): 613-623, 1982

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Original article

SERUM LEVEL OF PREGNANCY ASSOCIATED α₂-GLYCOPROTEIN(PAG) IN PATIENTS WITH BREAST CANCER
－CLINICAL AND IMMUNOLOGICAL SIGNIFICANCE OF THE PROTEIN－

The serum levels of pregnancy associated α₂-glycoprotein (PAG) which were qantitated by immunoelectrophoresis in terms of percentage of standard pregnant serums, were 26.28±16.97% (M.± S.D.) in 57 patients with benign breast tumor, 49.03±28.30% in 31 with preoperative breast cancer, and 62.64±28.16% in 25 with recurrent breast cancer.
The result showed that the serum level of PAG was significantly high in patients with preoperative or recurrent breast cancer compared with benign breast tumor.
Suppressive effects of serums from patients on transformation of PHA-induced lymphocytes which was shown as percentage of standard value in a certain male volunteers, were 11.73±6.90% in 9 patients with benign breast tumor, 21.96±13.90% in 13 with preoperative breast cancer, and 32.21±6.64% in 11 with recurrent breast cancer. PHA skin test to detect a non-specific immunoreactivity resulted in 35.88±8.32 mm in 16 patients with benign breast tumor, 27.78±7.86mm in 9 with preoperative breast cancer, and 23.89±9.53mm in 19 with recurrent breast cancer.
Significant correlation between the serum level of PAG and suppressive effect on non-specific immunity was observed.

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