J.Jpn. Surg. Soc.. 83(3): 297-307, 1982

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Original article

STUDIES ON ACUTE RENAL FAILURE IN OBSTRUCTIVE JAUNDICE

The renal functions were examined clinically and experimentally in order to clarify the etiology of postoperative acute renal failure in patients with obstructive jaundice.
Clinically, in 60 jaundiced patients with biliary diseases renal function was examined by free water clearance method. As jaundice became more serious, renal function became worse and particularly in the aged and in the postoperative period, decrease of renal function was more remarkable. Delay of recovery of renal dysfunction was also observed in the jaundiced.
Experimentally, jaundiced dogs were made by ligation of common bile ducts. Endotoxin was infused into the bile duct 4 weeks after ligation. All dogs were fell into a shock state immediately after intraductal pressure reached to 30cm H₂O. The Limulus tests of the blood and urine showed positive results. Endotoxic shock caused a decrease of renal blood flow. These findings suggest that bacteria in the bile will be one of the causes of acute renal failure.

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