J.Jpn. Surg. Soc.. 83(2): 137-149, 1982

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Original article

STUDY ON THE IMMUNOLOGICAL REACTIVITY OF CANCER PATIENTS
II. CYTOTOXIC ACTIVITY AND ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITY OF PERIPHERAL BLOOD MONONUCLEAR CELLS AGAINST ALLOGENEIC CULTURED TUMOR CELLS IN CANCER PATIENTS

Cytotoxic activity, antibody-dependent cellular cytotoxicity (ADCC) of peripheral blood mononuclear cells against allogeneic cultured tumor cells and the effects of autologous sera from the patients on cytotoxicity were examined in untreated patients with gastric cancer and breast cancer. Significantly depressed cytotoxic activity was observed in gastric cancer patients in the presence of autologous serum, although cytotoxic activity in breast cancer patients was suppressed in the presence of both homologous and autologous serum. Moreover, cytotoxic activity in cancer patients declined with the stages of disease, especially in the presence of autologous serum. It seemed that there existed two different serum effects, i.e., augmentation and suppression on cytotoxicity, and significant suppression of cytotoxicity was found in advanced cancer patients. ADCC activity against gastric cancer cells was suppressed in breast cancer patients. However, ADCC activity was higher in gastric cancer patients whose cytotoxicity against gastric cancer cells was augmented or suppressed by autologous serum as compared with that of normal healthy persons. Augmentation of cytotoxicity by autologous serum in early stage seemed to be induced by ADCC and suppression by autologous serum in later stages seemed to be due to serum suppressive factors.

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