J.Jpn. Surg. Soc.. 83(1): 38-52, 1982
Original article
IN VITRO POTENTIATION OF HUMAN NATURAL KILLER (NK) CELL ACTIVITY BY A STREPTOCOCCAL PREPARATION, OK-432
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Department of Surgery, Jichi Medical School, Tochigi Hiro Wakasugi |
Cell separation procedures revealed that cytotoxic activity augmented by the stimulants was considered to be mediated mainly not by adherent, phagocytic, IgG-Fc-receptor positive cells and Tcells, but by NK cells. Further studies revealed that monocytes did not contribute to the augmentation of NK cell activity. In addition, no direct activation of NK cells was found by OK-432-stimulated mononuclear cells. On the other hand, supernatant derived from non-adherent lymphocytes cultured with OK-432 augmented NK cell activity significantly. Sufficient amount of interferon and interleukin-2 activity was found in the supernatant, suggesting that interferon and/or interleukin-2 released in the supernatant of OK-432-stimulated lymphocytes may play a role in the potentiation of human NK cell activity.
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