J.Jpn. Surg. Soc.. 82(10): 1177-1187, 1981
Original article
THE EFFECT OF CORTICOSTERONE ON DEXTRAN-INDUCED SHOCK IN RAT
|
First Department of Surgery, Gunma University, School of Medicine Kimitaka Kogure |
Animals were divided into three groups, i.e., control (Group A), adrenalectomized (Group B) and corticosterone- treated (2mg/day for 4 days) with adrenalectomy (Group C). 0.1 ml/100 g B.W. of 5% dextran and 150 μg/rat of histamine were given i.v. to each rat, respectively.
Determination of plasma histamine (micromethod), Hct, B.P. and grade of edema were measured and the following results were obtained.
In Group B, higher histaminemia, remarkable hemoconcentration and intractable hypotension were observed and most rats died of shock without any recovery.
In both groups A and B rats returned normal within two hours and there were little differences between these groups.
These data suggested corticosterone accelerates the clearance of circulating histamine and inhibits the release of histamine from mast cell in dextran-induced shock. The role of histamine as chemical mediator in dextran-induced shock was also discussed.
To read the PDF file you will need Adobe Reader installed on your computer.