J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 6834KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 82(7): 739-747, 1981

Original article

EXPERIMENTAL STUDY OF THE INTRAOPERATIIVE IRRADIATION FOR LIVER CANCER

*) First Department of Surgery, Faculty of Medicine, Kyoto University
**) Department of Microbiology, Faculty of Medicine, Kyoto University
***) Department of Radiology, Faculty of Medicine, Kyoto University
****) Radiology, Shiga Medical College

Shigeki Arii*), Hidenari Takasan*), Shuichi Takahashi*), Chung II Kim*), Takao Uozumi *), Takayoshi Tobe*), Yohei Ito**), Mitsuyuki Abe***), Sumio Suyama****), Eizo Yabumoto****)

The resectability rate of the liver cancer is very low. Especially, hepatoma is apt to combine cirrhosis and its curability is poor as compared with malignant neoplasma of other organs. Therefore, the development of more effecitve adjuvant therapy for liver cancer is desirable. We studied the possibility of intraoperative radiotherapy with electron beams of Betatron. At first, we examined the influence of 5000 rad irradiation to approximately 1/2 area of the liver on the aspect of the serological liver function and histology using the domestic rabbits. Following this experiment, we used Vx2 carcinoma transplanted into the livers of the rabbits as the simulation model of the human liver tumors and examined the effect of irradiation to the tumor and its surrounding liver tissue.
Results
1. The rabbits irradiated with 5000 rad to approximately 1/2 area of the liver intraoperatively grew healthily without severe dysfunction of the liver.
2. On the histological examination, degeneration and necrosis of the parenchymal cells appeared at the small parts of the irradiated area at the earlier periods of irradiation, but the necrotic regions did not get wider in range. Subsequently, liver fibrosis progressed gradually.
3. Irradiation to the rabbits transplanted Vx2 carcinoma resulted in the prolongation of the life spans and the diminution of the tumors.

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