J.Jpn. Surg. Soc.. 82(7): 702-707, 1981
Original article
PATHOPHYSIOLOGY OF ENDOTOXIN SHOCK IN HYPERDYNAMIC STATE
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1) The 2nd Department of Surgery, Kagoshima University Koro Sakoda1), H. Grafelmann2), R. Schosser2), K. Messmer2) |
Male sprague Dawley rats were used as experimental animal and divided into three groups. Group I: normal rat. Group II: treated with intraperitoneal injection of saline solution. Group III: treated with intraperitoneal injection of 25mg/kg coli endotoxin. Mean arterial blood pressure (M.A.P.) was measured during experiment. Cardiac output and hepatic blood flow were determined using the radioactive microsphere technique. Hepatic PO2 was measured with a platinum multiwire electrode, and blood parameter (GOT, GPT, glucose etc.) were measured 30 min. after laparotomy in Group I, and before and after treatment of saline or endotoxin in Groups II and III.
There were no significant changes in MAP and cardiac output in three groups. An increase of GOT was more prominent in Group III than that of Group II. Blood glucose decreased remarkably in Gorup III compared with that of Group II.
Hepatic PO2 declined remarkably 6 hours after an administration of endotoxin while it was unchanged in Group II. However, changes in hepatic blood flow were not observed between Groups II and III.
These results suggest that a severe disturbances of the microcirculation and cellular metabolism in the liver may be induced in hyperdynamic state of endotoxin shock.
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