J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 7364KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 82(4): 368-377, 1981

Original article

PROTECTION OF EXPERIMENTAL STRESS ULCERS BY INHIBITION OF COAGULATION, FIBRINOLYSIS AND KININ SYSTEMS

*) Second Department of Surgery, Faculty of Medicine, Kyushu University
**) Department of Surgery, Hahnemann Medical College and Hospital, Philadelphia

Yoshifumi Kodama*)**), Teruo Matsumoto**), Kiyoshi Inokuchi*)

Effect of an anticoagulant, antifibrinolytic agents and kallikrein inhibitors on stress ulcers induced by cold and restraint in rats were studied. Intravenous administration of 50 U /Kg of heparin, 500 mg/ Kg of ε-aminocaproic acid and tranexamic acid, 50,000 KIU /Kg of aprotinin and 5.0 mg/Kg of gabexate mesilate before the exposure of cold-restraint stress significantly reduced the severity of gastric ulcerations and hemorrhage These doses of agents did not affect total acid output in pylorus-ligated rats. These results support a concept that thrombogenesis, fibrinolysis and kinin system in the gastric mucosa might play a role in the pathogenesis of stress ulcers and that these agents could be applicable for clinical use.

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