J.Jpn. Surg. Soc.. 82(3): 193-202, 1981

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Original article

AN EXPERIMENTAL STUDY OF PASSIVE CANCER IMMUNOTHERAPY BY INFUSION OF THE IMMUNE LYMPHOCYTES

First experiments were carried out to see whether cryoimmunity for cancer is induced. The tumors of rats were treated by freezing, and their peripheral lymphocytes were collected and infused into the other rats. It was observed by the challenge of the same tumor cells and MIT whether antitumor activity was transferred to these rats.
Results were:
1) The rats receiving the infusion rejected the challenge of tumor at a high frequency.
2) The lymphocytes collected from these rats inhibited specifically the migration of macrophage. From these results, the establishment of cryoimmunity in the primary rats was proved.
Further experiments were carried out to evaluate the effects of the same lymphocytes irifusion into the tumor-bearing rats.
Results were:
1) The remarkable inhibition of tumor growth and elongation of mean survival days were observed.
2) These effects depend on the dose of infused lymphocytes.
3) The remarkable infiltration of lymphocytes in the tumor tissue after infusion was seen by means of histological study.

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