J.Jpn. Surg. Soc.. 82(1): 34-41, 1981

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Original article

A COMPARATIVE STUDY ON THE PREOPERATIVE COMBINED CHEMOTHERAPIES WITH MITOMYCIN C AND 5-FLUOROURACIL (MF THERAPY), AND NEOCARZINOSTATIN AND 5-FLUOROURACIL (NF THERAPY) AGAINST GASTRIC CANCER

The present study was designed to evaluate the effects of preoperative chemotherapies with MF combined with NF on clinical and histological findings in patients with gastric cancer. In the MF therapy, 4 mg MMC and 500 mg 5-FU were administered to 36 patients (MF group) every other day, whereas in the NF therapy, 2 mg NCS (2000 Unit) and 500 mg 5-FU, dissolved in 500 ml pentose solution, were given to 25 patients (NF group) every other day. No remarkable side effect was observed in either MF or NF therapy and the combined therapy of both two. Degenerations of cancer cells were produced various layers of the gastric wall. The extent of degenerations depended on the number of MMC and 5-FU administrations in MF group, but not necessarily so in NF group. Comparing the degerative effects of more than 5 times drug administrations between the two groups, the degerations of cancer cells were more remarkable in NF group.
Examinations of cancer cells in the metastasized lymph node revealed that the degeneration in NF group treated more than five times was significantly higher than those in MF group, but in MF group, the extent of degenerations did not depend on the number of drug administrations. Histological examinations on various types of cancer cells showed that higher degenerations were observed in papillary adenocarcinomas, poorly differentiated adenocarcinomas and signet-ring cell carcinomas in NF group, however, the degenerations in MF group was not remarkable irrespective of histological type.

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