J.Jpn. Surg. Soc.. 81(11): 1468-1475, 1980
Original article
INSULIN AND GLUCAGON RESPONSES, AND HEPATIC EXTRACTIONS OF THESE HORMONS ON GLUCOSE STIMULATION IN OBSTRUCTIVE JAUNDICE
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1) The Department of Surgery, Yokohama National Hospital Mamoru Kobayashi1), Hiroshi Shimada2), Kazumi Sato2), Fumihiko Kito2), Koichiro Shinmyo2), Tetsuo Abe2), Shuzi Tsuchiya2) |
There were glucose intolerance and low insulin response in the jaundice group compared with the control group, but no difference on glucagon response between both groups.
Insulin and glucagon levels of peripheral and portal vein after glucose administration were studied experimentally in eight dogs with obstructive jaundice and in seven normal dogs as a control.
There were low insulin response in the early phase and high insulin response in the late phase in portal vein of the jaundiced dogs compared with the control dogs, although there was low insulin response in peripheral vein of the jaundiced dogs throughout the study.
There were no differences on glucagon responses in portal and peripheral vein between both groups.
But the jaundiced dogs showed high portal-peripheral-ratios of insulin and glucagon, which suggested that the accelerated hepatic extractions of pancreatic endocrine hormons is related to the action of hepatotrophic factor.
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