J.Jpn. Surg. Soc.. 81(9): 1134-1138, 1980
Report on the annual meeting
EFFECT OF TOTAL PARENTERAL NUTRITION ON THE NUTRITIONAL STATUS AND IMMUNOCOMPETENCE IN HOST AND ON THE TUMOR GROWTH
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School of Medicine, First Department of Surgery (Director: Prof. Yoichi Saitoh), Kobe University H. Ohyanagi, M. Sekita, S. Okumura, K. Toshima, Y. Murayama, M. Nishijima, M. Usami, F. Hiraishi, T. Harada, Y. Saitoh |
Donryu rats having a subcutaneously transplanted Satoh's lung cancer and patients with cancer involving chiefly alimentary tract were studied throughout experiments. TPN was compared with low calory infusion in relation to chemotherapy.
The well nourished TPN group maintained the immunocompetence well in chemotherapy or radiation. The duration of postoperative fall in immunocompetence due to surgical stress was shorten in TPN than in low calory infusion, revealing that its recovery was accelerated by TPN.
There was a greater tumor bulk in well nourished TPN rats compared with the malnourished group. Despite no significant change in polyamine level, thymidine kinase activity and mitotic index in tumor were significantly higher in TPN than in low calory infusion.
The tumor bulk and thymidine kinase activity in TPN showed the tendency of decrease by combined TPN and chemotherapy. Thus, the possibly increased tumor growth by TPN was revealed to be prevented by combined chemotherapy.
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