J.Jpn. Surg. Soc.. 81(9): 1078-1082, 1980
Report on the annual meeting
CHEMOTHERAPY AND HORMONE THERAPY ON HUMAN TUMORS TRANSPLANTED TO ATHYMIC NUDE MICE
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Department of Surgery, School of Medicine, Keio University, Tokyo, Japan Osahiko Abe, Tetsuro Kubota |
As the drug sensitivity of syngeneic tumors in nu/+ mice remained to some degree in nu/nu mice, human cancers transplanted to nude mice were demonstrated appropriate materials to evaluate chemotherapeutic agents for human carcinomas. In human tumors, the degree of tumor regression correlated well to doses of intraperitoneally injected MMC or FT-207, which indicated that these tumors were suitable materials for experimental chemotherapy. The combined administration of MMC and FT-207 revealed additive and synergistic effects on human gastric and colon carcinomas in the nude mice model.
Subsequently, MMC and FT-207 were administered in randomized gastric cancer cases receiving adjuvant chemotherapy following gastrectomy as follows:?
Group A (only MMC 20 mg intraop. + 10 mg 1 day postop.)
Group B (same doses of MMC as group A + FT-207 600―800 mg daily per os)
Three year survival rates were 65.8% in group A and 85.5% in group B. There was no significant difference between the two groups in background factors and side effects.
Furthemore, analysis of cell kinetics by impulse cytophotometry and experimental hormone therapy on estrogen regulated breast carcinoma (Br-10) were performed in the nude mouse model. From the results obtained, it was concluded that the humanーnude mouse system is a useful model not only for the screening of antitumor agents but also for analysis of cell kinetics and the mechanisms of chemotherapy and hormone therapy.
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