J.Jpn. Surg. Soc.. 81(9): 936-939, 1980
Report on the annual meeting
SIGNIFICANCE OF THE MEASUREMENT OF SERUM PANCREATIC ENZYMES AND PANCREATIC INHIBITOR IN ACUTE PANCREATITIS IN RELATION TO THEIR MOLECULAR FORM AND DISTRIBUTION IN THE SERUM
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Second Department of Surgery, Osaka University Medical School Michio Ogawa, Yuichi Takatsuka, Ken-ichi Fujimoto, Takeshi Kitahara, Shigenori Tanaka, Kishio Matsuura, Minoru Kurihara, Masanobu Masuike, Kenjiro Iwaki, Atsuo Murata, Naoki Takata, Masatoshi Ishida, Goro Kosaki |
Serum amylase level was significantly higher in necrotizing pancreatitis than interstitial pancreatitis. However, admission amylase level of 4 cases in necrotizing was within mean plus 1 S.D. of interstitral pancreatitis. No significant difference of serum E-2 was observed between two groups. In the serum, E-2 bound to serum protease inhibitors, α1-antitrypsin and α2-macroglobulin. Radioimmunoassayable E-2 was α1-antitrypsin bound E-2, a part of E-2 present in the serum.
In contrast, serum. PSTI content was significantly different between necrotizing and interstitial pancreatitis. PSTI in the serum is in free form and whole PSTI in the serum can be measured by a radioimmunoassay. Moreover, we found the elevation of serum PSTI was accompanied by some clinical manifestations and continued for a couple of weeks after the onset, even though serum amylase activity returned to the normal range.
It can be concluded that serum PSTI content could be of great value in the diagnosis and the evaluation of the severity of acute pancreatitis.
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