J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 2637KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 81(3): 242-246, 1980

Original article

STUDIES ON GLUCAGON RESPONSES TO GLUCOSE IN THE PATIENTS WITH GASTRECTOMY

The Second Department of Surgery, Hyogo College of Medicine
*) The Third Division, Department of Internal Medicine, Kobe University School of Medicine
**) The Second Division, Department of Internal Medicine, Kyoto University School of Medicine

Yoshinao Kotoura, Takehira Yamamura, Toku Takahashi, Naoki Hashimoto, Kenichi Yoshiya, Junro Miura, Yoshio Ishikawa, Nobuyoshi Ito, Tsutomu Chiba*), Kozaburo Mori*), Tomohiko Taminato*), Yutaka Seino**)

The present study was designed to examine the glucose tolerance in the patients before and after the total gastrectomy. The disappearance rate of glucose from the blood (k-value) and the plasma insulin response following intravenous 20 g glucose tolerance test significantly decreased after the operation, but no change in glucagon response. Blood glucose levels following 50 g oral glucose ingestion changed from normal pattern to mild glucose intolerance after the operation. In patients with total gastrectomy, plasma insulin response to oral glucose tended to be higher than those in preoperative subjects, while plasma glucagon which was decreased by oral glucose before the operation significantly rose after the operation. These results suggest that these elevated glucagon after oral glucose may contribute to the glucose intolerance in patients with total gastrectomy.

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