J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 6598KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 81(2): 164-174, 1980

Original article

EXPERIMENTAL STUDIES ON SURGICAL MORPHOLOGY CONCERNED WITH INTESTINAL FLORA

From the 2nd Department of Surgery, School of Medicine Kinki University, Sayama Osaka, Japan

Takeshi Kuyama

Inside the germfree isolator, gnotobiotic megacecum was resected and the ileocolostomy of microsurgery, that is performed by working gloves of germfree environmental chamber, was done in germfree rats. Fourteen days after this surgical operation, the megacolon and the atrophy of mucous membrane in colon were observed. In conventional rat which was fed in open room, the same surgery as above was done, but the pathological change the same as in gnotobiotes was never recognized. This dilatation of colon was presumably caused by the intoxication of bile acids, that is relating with inactivation of intestinal flora and metabolism of 17-Ketosteroid.

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