J.Jpn. Surg. Soc.. 80(12): 1589-1591, 1979

---

Report on the annual meeting

SUMMARY

We have been performed several research programs for the pathophysiology of the shock state and reported the results and our interpretation for each research theme. It is clear that we should put more effort to make this problem obvious.
Firstly, the initial tolerance could not be explained as specific reaction. If we incubate the hepatoma cells as target with the isolated macrophage, the target cells would not be damaged at all and also the macrophage not be affected by endotoxin.
However, the destruction of the target cells could be occured by the incubation of the hepatoma cells, endotoxin and the macrophage together. From these findings, it is tentatively concluded that the function of the RES namely macrophage or Kupffer cell is rather cytotoxic.
The innitial tolerance should be understood from the view point of interactions between cell systems as biological defence reactions in cellular level. The basic works of recently developped immunology must be useful means to resolve this phenomenon. Secondly, the experiments using the C3H/HeJ mouse which was known as unreactive animal against endotoxin would be helpful for this purpose. Thirdly, I believe the roles of the complements system, coagulation system, kinin system and plasmin system which are known as four major reaction system should be made clear. Homeostasis is kept by the interrelation and generalization among the Kupffer cell, lymphocyte (B-cell) and other cells.
It is considered that endotoxin gives toxious influences to this cellular information transmitting system and these phathophysiology as the important theme of study in shock state will have close connection with basic field of cellular immunology.

---

---

To read the PDF file you will need Adobe Reader installed on your computer.