J.Jpn. Surg. Soc.. 80(12): 1562-1565, 1979

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Report on the annual meeting

SEPTIC SHOCK

Secondary shock occuring in patients with infection is called septic or bacterial shock, the most typical examples of which are seen in bacteremia and/or endotoxemia detected by limulus lysate test. Sixty-three patients of bacteremia and 136 patients of endotoxemia, chiefly recognized in acute peritonitis or biliary infection, were presented. Several characteristic findings such as hyperdynamic state, hypoglycemia, and serum complement cascade, were discussed in detail.
It might be golden rule for the modern improved therapy of septic shock that, rational and careful transfusion through monitoring such indicators as CVP, blood pressure, urinary output, and PAWP (Swan-Ganz catheter), timely administration of various vasoactive substances, cardiotonica, and massive dose of steroids, are all of importance. Taking into consideration of the frequency of multiple vital organ failures, appropriate measures should be also taken not only for the restoration of hypotension, but also for prevension of those organ failures. Some new therapeutic development of severe septic shock in terms of administration of hypertonic glucose solution, prevention of initial fall of blood pressure by indomethacin, and protection of gastric mucosa from acute alceration by cimetidine were presented.

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