J.Jpn. Surg. Soc.. 80(12): 1437-1440, 1979

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Report on the annual meeting

IMMUNOSUPPRESSIVE FACTORS IN CANCEROUS SERA AS THE IMMUNOLOGICAL PARAMETER

Sera from patients with carcinomas markedly suppressed the normal lymphocyte response to phytohemagglutinin (PHA) when compared with normal sera. The effect of this suppression was well correlated with the degree of advance of the disease.
The suppressive activity of cancerous sera was decreased within three or four weeks after the successful procedure of tumor extirpation. Moreover the suppressive activity of sera was markedly diminished in well-controled group by immunochemotherapy. So, a definite relationship between suppressive activity of sera and clinical status was noted in cancer-patients.
Fractionation of normal and cancerous sera was carried out by DEAE-cellulose column chromatography using a continuous concave gradient. The elution patterns of two kinds of sera were quite similar and separated into nine fractions. The suppressive activities of cancerous sera on PHA response of normal lymphocytes were found in α-globulin, β-globulin and α₂-macroblobulin fractions. The electrofocusing patterns of α₂-macroglobulin fractions obtained from normal and cancerous sera showed a remarkable difference in protein composition.
These results indicated the measurement of immunosuppressive activity of sera is the better way to examine the immunological status in cancer-patients.

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