J.Jpn. Surg. Soc.. 80(12): 1399-1402, 1979

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Report on the annual meeting

ENHANCEMENT OF METASTASIZED TUMOR GROWTH IN RATS AFTER TREATMENT OF PRIMARY TUMOR BY CRYOSURGERY

A syngeneic transplantable fibrosarcoma; KMT-17 in WKA/Hok rats was treated by cryosurgery 5 days after the subcutaneous transplantation resulting in 15 out of 31 rats (48.8%) dying of tumor metastases, though a primary tumor was cured in all cases. On the contrast, by surgical excision of the primary tumor only 4 out of 34 rats (11.8%) died of tumor metastases. Tumor cells in regional lymph nodes could be detected 5 days after the transplantation by intraperitoneal implantation into irradiated (250 rads) syngeneic rats in a half of non-treated rats as well as in a half of rats treated by cryosurgery and surgical excision of the primary tumor one hour before the detection. Development of antitumor immunity was evidented to delay in rats treated by cryosurgery as compared with rats treated by surgical excision, as being investigated by rechallenge of tumor and Winn's assay. Removals of cryonecrotized tissue after the cryosurgery of the primary tumor by surgical excision reduced the death rate of metastasis and implantations of cryonecrotized tumor cells after surgical excision increased the death rate of metastasis. Thus, enhancement of metastasized tumor growth was immunological phenomenon and due to cryonecrotized tumor tissue.

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