J.Jpn. Surg. Soc.. 80(11): 1139-1141, 1979

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Report on the annual meeting

PROBLEMS IN THE TREATMENT OF ACUTE THROMBOSIS DUE TO ARTERIOSCLEROSIS

Forty one patients with arterial thrombosis were analysed. Among of 28 cases treated by the surgical reconstruction, 17 cases (60. 7%) represented successful results, however, diseased extremities were amputated in 7 cases (25%). Medical treatment were carried out in 13 cases, in which extremities survived in 8 cases (61.5%) and were amputated in 5 cases (38.5%). Thus, surgical treatments were essentially much better than medical therapy, however, the mortality rate was higher in the former than in the latter. The main cause of death of 9 cases (22%) in our series was myonephrotic-metabolic syndrome (4 cases).
Biochemical and enzymological changes were daily examined in 20 patients. Rhabdomyolysis, nephrosis and metabolic acidosis were observed in 6 cases (30%) with severe extensive ischemia. On those changes, there is no practical difference between de-and revascularization phases.
Experiments using 50 dogs demonstrated various pathophysiological changes in myonephroticmetabolic syndrome.
A definite principle of treatment for arterial thrombosis were discussed based on those clinical and experimental studies.

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