J.Jpn. Surg. Soc.. 80(11): 1062-1066, 1979

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Report on the annual meeting

ORTHOTOPIC LIVER TRANSPLANTATION IN DOG AND RAT

We have searched for a new technical method in orthotopic liver transplantation without temporaly external bypass in dog. This method has no unhepatic phase during the operation. Orthotopic liver transplantation was carried out on 45 dogs. All dogs survived more than 2 days without immunosuppresant. The mean survival was 7.9±5.5 days. Thirty one of 35 dogs survived more than 2 days and 14 out of 31 dogs survived more than 20 days with immunosuppresant. The longest survival was 124 days.
This new method was also applied to rat experiment. Orthotopic liver isotransplantation were performed. Six of 10 rats survived more than 2 days and 4 rats survived more than 150 days. This simplified technique of orthotopic liver transplantation in dogs and rats can be applied to study of liver physiology and immunology.
We investigated the active enhancement of liver homograft in 22 pairs of beagle dogs by pretreatment with semisoluble donor specific antigen. If the antigen were administered together with prednisolone, survival time was significantly prolonged. Two dogs survived more than 3 years. We found no correlation between the survival time and the titer of lymphocytotoxic antibodies in the recipient sera.

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