[
Abstract]
[
Full Text PDF] （in Japanese / 1846KB）
[Members Only And Two Factor Auth.] J.Jpn. Surg. Soc.. 80(11): 1047-1051, 1979
Report on the annual meeting
A ROLE OF HYPOTHERMIA IN CARDIAC PRESERVATION: AN ESTIMATION THROUGH EXPERIMENTAL TRANSPLANTATION
Fundamental factors in cardiac preservation has been pursued experimentally in dogs. Cadaver hearts with 30-40 minutes of warm ischemia were preserved for 60 minutes by means of hypothermic coronary perfusions with diluted blood (30% of hematocrit), EL-3 (35 mEq/1 of K
+), and modified Krebs (6.2 mEq/1 of K
+). Grafts were transplanted orthotopically to recipients using cardio-pulmonary bypass. Sixteen out of 20 with blood, 11 out of 14 with EL-3, and 9 out of 14 with modified Krebs perfusions revealed excellent recovery of cardiac function after transplantation. There were insignificant differences in results among three groups. Therefore, the next experiment was focused on the determination of fundamental factors in cardiac preservation. EL-3 and modified Krebs solutions in normo and hypothermia were infused every 30 minutes into the coronary artery of the canine heart with aortic cross clamping for 90 minutes under cardio-pulmonary bypass. Restoration of cardiac function after declamping was 100 percent in hypothermia groups, whereas it was 50 and 0 in normothermic EL-3 and modified Krebs, respectively. Thus, the conclusion has been made that the hypothermia play the most important role in cardiac preservation.
To read the PDF file you will need Adobe Reader installed on your computer.