J.Jpn. Surg. Soc.. 80(10): 931-940, 1979

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Original article

STUDIES ON FUNCTIONAL RESERVE AND RESECTABILITY OF THE LIVER WITH OBSTRUCTIVE JAUNDICE IN DOGS

On the radical operation in obstructive jaundice due to carcinoma of the hilar area in the liver, it might be necessary to resect the liver with obstructive jaundice, but there are many complications and a high mortality. Therefore, it is very important to evaluate the surgical risk and to select operation-methods prior to surgery in these patients.
The purpose of this study was to evaluate hepatic functional reserve using maximal removal rate of indocyanine green (ICGRmax) and the other functional tests of the liver, and to estimate resectability of the liver with obstructive jaundice in dogs.
On basic study, it revealed that ICGRmax was useful in spite of being hyperbilirubinemia and reflected the accurate liver function. Resectability of the liver with obstructive jaundice in dogs was clearly shown preoperatively by ICGRmax, although it was very difficult to evaluate exactly the surgical risk by the routine liver function test or hepaplastin test. Furthermore, ICGRmax was also significantly correlated with liver regeneration rate calculated by Child's formula, and so it concluded that ICGRmax was very useful to estimate hepatic functional reserve.
On the other hand the prognosis after hepatectomy is related to functional reserve of the remaining liver, therefore it is desirable to estimate functional reserve of the remaining liver, especially in major hepatic resection.

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