J.Jpn. Surg. Soc.. 80(10): 902-915, 1979

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Original article

EXPERIMENTAL STUDIES ON MECHANISM OF FORMATION IN STRESS ULCER－MAINLY ON ACTIVITIES OF AMINES IN THE BRAINS AND THE GASTRIC MUCOSA

The author inflicted restrained and water-immersion stress on intact, vagotomized and adrenalectomized rats, respectively, and investigated the correlation between stress ulcer formation and variations of amines in the brains and the gastric mucosa, changes of gastric movement and gastric acidity. In the intact group, ulcer formations were observed in all cases by stress infliction. Brain amines showed diminution of NA and decreasing trend of 5-HT, but DA, AD and HA showed no change. Each amine in the gastric mucosa showed decrease after stress. It was considered that ulcer was produced on mucosal micro-circulatory disturbance by this released amines in addition to acceleration of gastric motility and hyperacidity. Brain amines of vagotomized group showed similar change to intact group, however, amines in the mucosa varied a little and acceleration of gastric motility and hyperacidity were not observed and ulcer formation was remarkably restrained. This was considered that stress attack from the nerve center was chiefly through the vagus and variations of each factor of the stomach were restrained by vagotomy. Brain amines in adrenalectomized group, HA and 5-HT showed similar tendency to other two groups, but NA, AD and DA decreased before stress, and NA decreased after stress. Mucosal amines, especially NA and HA, showed remarkable diminution and gastric motility was accelerated from an early stage. Ulcer was earlier produced than intact group, and that deteriorated. As the result, it was considered that the adrenal gland was not essential to participation of ulcer formation, but had preferably restraint action.

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