J.Jpn. Surg. Soc.. 80(10): 861-873, 1979

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Original article

EXPERIMENTAL STUDY ON RATIONAL IMMUNOCHEMOTHERAPY

To establish the rational immunochemotherapy, delayed hypersensitivity reaction (DHR) to picryl chloride was observed in tumor bearing ddN mice, treated with immunopotentiators, such as Streptococcal preparation (OK-432) and PSK.
DHR in the groups treated with continuous administration of immunopotentiators was much stronger than in untreated group on the twelfth day. On twenty-fourth and thirty-sixth day, however, it was the same in the treated group and in the untreated group.
The group treated with intermittent administration of immunopotentiators prevented the fall of DHR throughout.
In the combined treatment of mitomycin C plus OK-432 or carbazilquinone plus PSK, much higher DHR and much longer survival were observed in the group, when immunopotentiators were administered intermittently.
From the experimental data, continuous administration of immunopotentiators might lead to the"exhaustion" of immunological potency of the tumor bearing host. To restore this "exhaustion", intermittent administration of the immunopotentiators was proved to be effective.

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