J.Jpn. Surg. Soc.. 80(9): 812-819, 1979
Original article
A CLINICAL STUDY ON BILE ENZYME ACTIVITIES IN BILIARY TRACT INFECTION
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The First Department of Surgery, University of Hokkaido, School of Medicine Motoki Yonekawa, Akio Kawamura, Takeshi Minamida, Norio Kawanishi, Yoichi Kasai |
Among serum enzyme activities, only Al-p was in higher level in infectious cases than in non-infectious ones.
In bile, GOT, GPT and Al-p activities had no significant difference between infectious cases and non-infectious ones. LDH activity range in infectious cases was 72-2,450 units and was 21-61 units in control cases. The difference of the LDH activities between the two groups was highly significant (p＜0.01). The high LDH level in infectious cases might result from that the epithelial cell and WBC were broke down due to infection, and the enzymes were liberated from those necrotic cells.
The clinical courses of the patients were related to the change of bile LDH activity on serial determination. When bile LDH activity was in low level, the bile drainage was functioning for reduction of jaundice, but the persistence in high level of bile LDH activity showed poor results.
This study indicates that the determination of LDH level in bile should be valuable in evaluation of the drainage effect.
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