J.Jpn. Surg. Soc.. 80(9): 798-811, 1979
Original article
AN EXPERIMENTAL STUDY ON THE ENHANCED SUPPRESSIVE EFFECT OF AN ANTITUMOR AGENT AGAINST MESENTERIC LYMPH NODAL METASTASES BY CLAMPING OF THE PORTAL VEIN
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Second Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan (Director : Prof. K. Inokuchi) Tadashi Kano |
1. The clamping of the portal vein for 10 minutes just after an intravenous administration of mitomycin-C showed an increased tissue level of the drug in the mesenteric lymph nodes as compared to that of the control animals.
2. Intravenous injection of mitomycin-C following the portal vein clamping for 10 minutes resulted in a high concentration of the drug in lymph nodes.
3. Mesenteric lymph nodal metastases were detected in 70 per cent of rats at the 7th day after inoculation of rat ascites hepatoma (AH-100B) into the mesentery. When the portal vein clamping with simultaneous intravenous injection of mitomycin-C was applied 7 days after tumor inoculation, the growth of lymph nodal metastases was strikingly suppressed examining 14 days after tumor inoculation.
4. Microscopic observation of capillary circulation of the mesentery showed marked enlargement of the capillaries and increased extravasation of a dye administered intravenously with portal vein clamping.
5. The biological influence of the portal vein clamping on the circulatory dynamics and appearance of endotoxemia was investigated, showing 10-minute clamping had no harmful effect.
6. From these facts it is reasonable to presume that the combined use of portal vein clamping and simultaneous intravenous injection of an antitumor agent induces an increased tissue level of a drug in the lymph nodes thereby producing an enhanced suppressive effect on lymph nodal metastases without any side effects.
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