J.Jpn. Surg. Soc.. 80(9): 781-797, 1979
Original article
EXPERIMENTAL CHEMOTHERAPY OF HEPATOCELLULAR CARCINOMA SERIALLY TRANSPLANTED IN NUDE MICE
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Department of Surgery, School of Medicine, Keio University Shuhei Iida |
Li-4 showed transformation to poorly differentiated adenocarcinoma in nude mice, but the other tumors (Li-7 and Li-16) revealed identical histology and function with the original tumors of the patients. These two tumors produced human α-fetoprotein, albumin and transferrin, and the concentration of these tumor markers in the serum increased with tumor growth and decreased with tumor regression.
Mitomycin C showed significant inhibitory effects on all these tumors while Adriamycin showed no significant effects. Tumor regression by chemotherapy was reflected by the decrease in level of tumor markers in the serum and histological findings. Therefore, efficacy of chemotherapeutic agents can be evaluated on the basis of size and weight of the tumor, histological findings as well as tumor markers.
Of the tumor markers, serum α-fetoprotein is the most useful parameter in that it has the most short half-life and is most sensitive.
It is concluded that experimental chemotherapy using these transplantable tumors gives clues to effective chemotherapy for human hepatocellular carcinoma.
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