J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 6050KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 80(9): 763-773, 1979

Original article

STUDIES ON SERUM IMMUNOSUPPRESSIVE EFFECTS OF GASTRIC CANCER PATIENTS
－In Particular Reference to Escape Mechanism from Anti-Tumor Cell-Mediated Immune Responses－

First Department of Surgery, School of Medicine, Chiba University, Chiba

Masaru Miyazaki, Shigeru Fujimoto, Kenjiro Itoh

Serum Effects of 46 gastric cancer patients and 17 normal persons on phytohemagglutinin (PHA)- and tumor associated antigens (TAA)-induced lymphoproliferative (LP) responses were investigated. PHA-induced LP responses were progressively decreased in autologous serum supplemented cultures as stage of cancer went on. Serum of gastric cancer patients in stage III and IV had remarkable suppressive effects as compared with normal persons (P＜0.01). As well, in the effect on TAA-induced LP responses, cancer patients serum had obvious suppressive activities in stage I (P＜0.10), II (P＜0.05), III (P＜0.01) and IV (P＜0.05).
Serum dose-response study of immunosuppressive effects revealed that cancer patients with positive tumor specific SI (SI≧2.0) had more remarkable activities than other cancer patients with 0.5＜ tumor specific SI＜ 2.0.
Serum suppressive effects on TAA-induced LP responses were closely correlated with tumor specific SI (r= -0.669, P＜0.001). Anti-tumor cell-mediated immune responses of cancer patients' lymphocytes were almostly suppressed by addition of cancer patients' autologous serum on lymphocytes cultures. There were no obvious relationships between serum immunosuppressive activities and serum CEA levels in gastric cancer.

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