J.Jpn. Surg. Soc.. 80(8): 707-716, 1979
Original article
AN EXPERIMENTAL STUDY ON THE ENHANCED SUPPRESSIVE EFFECT OF THE CHEMOTHERAPEUTIC AGENTS AGAINST ABDOMINAL TUMOR GROWTH BY CLAMPING OF THE PORTAL OR HEPATIC VEIN
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Second Department of Surgery, Faculty of Medicine, Kyushu Univercity, Fukuoka, Japan (Directou : Prof. K. Inokuchi) Kenzo Wakasugi |
1. The volume of lymph flowing through the thoracic duct was increased by portal vein clamping, and in such conditions, the lymph level of intravenously administered mitomycin-C was increased.
2. The concentration of mitomycin-C in the stomach and the small intestine of rats with the portal vein clamping was 5 fold higher than the levels in the control animals. A 2-to-3 fold increase was noted with bleomycin and 5-fluorouracil. The level of 5-fluorouracil in the transplanted tumor was markedly increased with portal vein clamping.
3. The growth of tumor inoculated into the mesentery at the root of the cecum was strikingly suppressed by the combined use of mitomycin-C and portal vein clamping. Of particular interest was a significant decrease in the number of foci of lymphatic metastases and of peritoneal dissemination after clamping.
4. The level of intravenously administered mitomycin-C in the liver of rats was increased with hepatic vein clamping.
5. The effect of hepatic vein clamping on the effectiveness of mitomycin-C against experimental liver tumor was dependent on the method of tumor inoculation. Tumor inoculated into the liver parenchyma was partially suppressed in its growth, but tumor inoculated into the portal vein was not suppressed. It rather showed an enhanced growth rate with hepatic vein clamping.
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