J.Jpn. Surg. Soc.. 80(7): 658-666, 1979
Original article
EFFECT OF REMOVAL OF REGIONAL LYMPH NODES ON HOST'S TUMOR IMMUNITY
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Hirotomo Kanayama, Hidetoshi Oku, Yasuaki Hirai, Ryuichi Hamazoe, Norio Shimizu, Michio Maeta |
By subcutaneous transplantation of Ehrlich carcinoma cells in syngeneic mice, the basic experimental design was as follows. In Experiment I, normal mice were subjected to removal of regional lymph nodes one week prior to transplantation and divided into four groups in challenge dose of Ehrlich carcinoma cells. After transplantation, its effect on tumor growth was observed in each group. In Experiment II, removal of regional lymph nodes was performed in Ehrlich carcinoma-bearing mice, which were grouped by the time of the operation. And respectively its effect on subsequent tumor growth was observed. In Experiment III, removal of regional lymph nodes was done either one, two, or three weeks after extirpation of the tumor (Ehrlich carcinoma) and respectively Ehrlich carcinoma cells were subsequently challenged. Then the host's resistance to the growth of the challenge tumor was observed.
The results showed that the tumor growth was enhanced when the regional lymph nodes were removed before or early after the transplantation. Furthermore, when the carcinoma cells were challenged early after extirpation of the tumor the removal of regional lymph nodes resulted in decrease of hose's resistance to the challenge tumor.
From these findings, it was assumed that regional lymph nodes might be significant as a source of host's immunologic activity and that removal of regional lymph nodes might impair host's resistance against tumor.
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