J.Jpn. Surg. Soc.. 80(6): 527-541, 1979

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Original article

EFFECT OF VAGOTOMY ON LIVER FUNCTION
(FIRST REPORT)

The effect of various vagotomy at gastrectomy to liver function was examined by means of preoperative and post-operative check of liver uptake rate (ku) and excretion rate (Ke) of ¹³¹I-BSP.
1) Studied were 43 cases of gastric cancer, 30 of duodenal ulcer, 27 of gastric ulcer, and 28 of control cases.
2) Those cases were grouped as follows : 28 cases of control group 29 cases of non-vagotomy, 30 of selective vagotomy and 39 of total vagotomy. In total vagotomy cases, pre-operative Ku was 11.73±3.38%/min, which lowered to 9.86±3.51%/min post-operatively. Pre-operative Ke 0.58±0.25%/min was also lowered to 0.34±0.17%/min post-operatively. This finding was much more significant to other three groups.
3) The lowering ratio of pre-operative Ku & Ke to post-operative Ku & Ke was about 10% in group of control cases, non-vagotomy and selective vagotomy. In total vagotomy cases, Ku was 16.45%, and Ke was 40.90%. This is highly significated Ke was much longer than Ku.
4) Recovery rates one year after in the follow-up examination, Ku was 87.06% and Ke was 71.19% in total vagotomy cases. Ke showed not as good recovery as Ku.
5) In cases of total vagotomy, no response to the insulin were obsered, such as Ku and Ke showed no significant changes whether insulin was given or not.
6) Above findings for the total vagotomy cases, the condition is almost same as that of vagal nerve brock induced by atropine administration.

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