J.Jpn. Surg. Soc.. 80(5): 398-411, 1979
Original article
EXPERIMENTAL AND CLINICAL STUDIES ON THE EFFECT OF IN-VIVO STAINING OF PARATHYROID GLANDS WITH TOLUIDINE BLUE
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The First Department of Surgery, Hokkaido University School of Medicine (Director : Prof. Yoichi Kasai) Fumimoto Imamura |
In rats, for identification of parathyroid gland, adequate dose of toluidine blue was 10 to 14 mg/kg body weight. Parathyroid glands were mostly stained showing similar density of the color to that of thyroid glands at one minute after the intravenous injection. It became easy to identify from 20 minutes after the injection, because the color of thyroid glands was faded more rapidly than that of parathyroid glands. However, it was difficult to identify parathyroid glands by a dose of toluidine blue over 14 mg/kg body weight, because both the parathyroid glands and thyroid glands were stained even one hour after the injection. Lymph nodes were stained faintly.
For human patients, toluidine blue was dissolved at 10 mg/kg body weight in 5% glucose 500 ml and administrated intravenously at 8 ml/min during the operation. The normal parathyroid glands were stained in 14 out of 26 patients with thyroid gland diseases. Parathyroid glands of younger patients were stained better than that of elder patients. Parathyroid tumors, in 7 out of 9 patients, were stained.
There was no remarkable side effect and influence on function of parathyroid glands and thyroid glands by toluidine blue.
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