J.Jpn. Surg. Soc.. 80(4): 334-344, 1979

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Original article

EXPERIMENTAL AND CLINICAL STUDIES ON HARDENING OF THE ARTERIAL WALLS AND ARTERIAL PULSE WAVE

In Japan, similarly as in Western countries, incidence of diseases due to impaired blood circulation has been increasing steadily of late. In the present study the following experiment was conducted in an effort to establish the noninvasive method of estimating the degree of arteriosclerosis, as one of pathophysiological factors of peripheral circulatory failure, at peripheral arteries.
The femoral arteries of mongrel adult dogs were allowed to be infiltrated by 1% aqueous solution of formalin either from the lumen or from the outer wall so that the elasticity of the arterial walls might be diminished. Using the arterial segments so treated, sphygmography and measurements of other hemodynamic parameters were made both in vivo and vitro.
The results indicated that hardening of the arterial walls was associated with a decrease in pressure gradient, a decrease in distensibility gradient, to pressure gradient, the appearance resonant waves, and a change of overall pulse wave form from a beads-like or spindle shape to a bar-like cofiguration. Similar findings were obtained from actual clinical cases.

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