J.Jpn. Surg. Soc.. 80(4): 321-333, 1979

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Original article

EXPERIMENTAL STUDY ON PULMONARY CIRCULATORY DISTURBANCES IN THERMAL INJURY, ESPECIALLY MICROSTRUCTURAL CHANGES OF THE LUNG AS RELATED TO TREATMENT WITH VARIOUS PARENTERAL SOLUTIONS

In an attempt to investigate the effect of replacement solutions on ultrastructural changes of the lung occurring in association with burns, the following experimental study was undertaken. Golden hamsters were exposed to boiling water at 100°C for 10 seconds without anesthesia to produce third degree burn involving 50% of the body surface. The burned animals were then either (I) left untreated (controls) or treated with (II) lactate Ringer's solution with glucose (LRG), (III) LRG plus 100 units/kg of heparin sodium (HEP), (IV) hypertonic lactated saline solution containing 200 mEp/L of Na (HLS 200) or (V) HLS of Na concentration of 300 mEp/L (HLS 300). The animals in these 5 treatment groups underwent electron microscopic examination of the lung at 30, 60 and 90 minutes after the thermal injury. The results are summarized as follows:
1. Changes in the lumina of capillary vessels were less severe in the HLS group than in the other 4 groups.
2. There was no substantial difference between any two of the treatment groups in the degree of alterations in the air-blood barrier.
3. Changes in type II alveolar epithelial cells were mildest in the HLS 200 group among the 5 treatment groups.
4. Interstitial edema was somewhat less prominent with replacement therapy with HLS 300.
In the last analysis, the results of the present study indicate that HLS proved to be better than any of the parenteral solutions used in replacement therapy, although there were no striking differences between these fluids.

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