J.Jpn. Surg. Soc.. 80(2): 164-172, 1979

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Original article

THE TREATMENT OF SEPSIS WITH INTRAVENOUS ADMINISTRATION OF ATP-MgCl₂ AND GLUCOSE
―Change of Hepatic Cellular ATP Level and Reticuloendothelial Function―

Since previous studies have shown a salutary effect of ATP-MgCl₂ administration on survival of animals following hemorrhagic shock and postischemic hepatic failure, the present study was undertaken to determine if ATP-MgCl₂ would improve the survival of animals with sepsis. Sepsis was prouced in rats by the cecal ligation and punctures, and the gangrenous cecum was removed 16 hours after the ligation and punctures which was followed by peritoneal lavage. Then animals received either 1) ATP-MgCl₂ (0.75 ml, ATP 100 μmoles, MgCl₂ 50 μmoles) +glucose (50%, 2 ml) 2) ATP-MgCl₂ alone, 3) glucose alone or 4) saline (non-treated).
Survival rate, hepatic cellular necleotides level and reticuloendothelial function were studied following the treatments. The animals which were treated with the combination of ATP-MgCl₂ and glucose showed the significant improvement of the survival (80%) compared to the non-treated animals (45%), or animals treated with ATP-MgCl₂ alone (30%), or with glucose alone (20%), This improvement of survival among the animals treated with ATP-MgCl₂＋ glucose was accompanied with the improvement of reticuloendothelial function which was impaired during the sepsis. Pulmonary uptake of RE test emulsion was enhanced in the non-treated group, and this enhanced uptake was reduced with the ATP-MgCl₂＋ glucose treatment. Hepatic cellular ATP level was recovered by the administration of ATP-MgCl₂. This recovery of ATP level and improvement of RES function could be one of the mechanisms of the beneficial effect of ATP-MgCl₂ and glucose treatment for the septic rats.

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