J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 2395KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 80(2): 141-146, 1979

Original article

A SKIN LESION ASSOCIATED WITH BIOTIN DEFICIENCY STATE DURING LONG TERM TOTAL PARENTERAL NUTRITION

*) The First Department of Surgery, Chiba University School of Medicine
**) The Department of Dermatology, Chiba University School of Medicine

Yoshiya Mashima*), Yoshitsugu Tanabe**), Masaru Fujita**), Yasuo Aoki*), Hideo Adachi*), Suwandi K.*), Kenjiro Itoh*)

A protoracted skin lesion, showing every characteristic of psoriasis, in 45 year old man, during long term TPN including fat emulsion and trace amount of Zinc in the formula. Cessation of biotin administration provoked a reccurence of the eruption which subsided again by the restoration of biotin injection. The serum biotin concentration and the urinary biotin excretion during these period were (a) less than 0.5 mμg/ml and 0.52 μg/day before administration of biotin (b) 1.5 mμg/ml and 12･32 μg/day or 1.86 mμg/ml and 51 μg/day after biotin was added to the formula respectively. These indicate that a state of biotin deficiency will occur and may cause a skin lesion which can not be successfully treated by the administration of essential fatty acid and trace amount of zinc during long term TPN, and also suggest that 0.5 mg/day of biotin may enough for the adult daily requirement for TPN.

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