J.Jpn. Surg. Soc.. 80(1): 32-41, 1979
Original article
HORMONE THERAPY IN POSTOPERATIVE CASES OF DIFFERENTIATED THYROID CANCER
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Department of Surgery, Iwate Prefectural Central Hospital Masahiro Oda |
TRH test was performed in 87 cases after surgery for differentiated thyroid cancer ; 38 cases had total thyroidectomy and 49 cases had subtotal thyroidectomy. These 87 cases were divided into three groups by the dose of thyroxine ; Group A was taking thyroxine less than 2.5 mcg/kg/day, group B was taking 2.5ｰ3.5mcg/kg/day and group C was taking more than 3.5 mcg/kg/day. All patients were given TRH (0.5 mg) IV and the serum TSH was measured at 30 minutes. In group A, the serum TSH was increased in all cases more than 10 mcU/ml. In group B, the serum TSH was increased more than 10 mcU/ml in 4 cases, but stayed lower than 10 mcU/ml in 25 cases. In group C, the serum TSH of all cases stayed lower than 10 mcU /ml or did not change after TRH injection.
These results lead to the following conclusion : The minimum dose of thyroxine necessary to suppress TSH secretion is 3.5 mcg/kg/day.
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