J.Jpn. Surg. Soc.. 79(9): 1094-1098, 1978

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Report on the annual meeting

SOLID-FORM ANTI-CANCER AGENT (BLEOMYCIN) FOR A ACTIVE ADJUVANT TREATMENT AT THE TIME OF SURGERY OF CANCER

Surgicaly scattered cancer cells and micro-metastases of the remained lymphnodes at the time of lymphnode dissection are speculated to be a major facter of local recurrence. To prevent this type of recurrence, we have developed solid-form anti-cancer agent which was intended to be given locally and to be slowly absorbed through the surrounding tissue containing possible minimum rsidual disease. We have initially tried Bleomycin in solid form packed in Argyl infant freeding tube, which is to be placed near the dissected area (upper mediastinum or upper abdomen) of metastatic lymphnodes at the time of surgery.
The tube was removed at seven days after operation. I have applied this method during period from March 1975 to March 1978 in total 45 cases of cancer of the esophagus. The prognosis for the patients with stage 4 treated by this new method was apparently besser than that for the patients without this treatment (historical control). In this new therapeutic group, there no patients with abdominal lymphnodes metastases after operation. Any serious side-effects have not been noted so far.

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