J.Jpn. Surg. Soc.
ISSN 1880-1129

[Abstract] [Full Text PDF] （in Japanese / 1316KB） [Members Only And Two Factor Auth.]

J.Jpn. Surg. Soc.. 79(9): 1089-1093, 1978

Report on the annual meeting

PREOPERATIVE ORAL ADMINISTRATION OF 5-FU EMULSION FOR STOMACH CANCER

*) Department of Surgery, Akita University School of Medicine
**) Department of Surgery, Kyoto Prefectural University of Medicine

Toshio Takahashi*), Kenichi Kono*), Toshiharu Yamaguchi*), Takehiko Soeno*), Tomio Narisawa*), Bunzo Nishioka**), Susumu Majima**)

Utilizing the lipid-absorbing ability of lymphatic capillaries, anticancer agents were given in the form of fat emulsion in order to deliver them to regional lymph nodes. Oral administration of emulsified 5-Fluorouracil (5-FU) was attempted for stomach cancer. With 5-FU, the maximum concentration of drug in thoracic lymph and stomach was greater when administered as an emulsion than as an aqueous solution, and a high concentration persisted longer. As a clinical trial of the emulsion method, 165 patients were given 5-FU emulsion orally. From the macroscopical and histological findings it was thought that the emulsion enhanced the chemotherapeutic effect of the anticancer agent on lymph node metastasis as well as stomach cancer.

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