J.Jpn. Surg. Soc.. 79(8): 860-864, 1978

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Report on the annual meeting

DYNAMICS OF CEREBROSPINAL FLUID CIRCULATION: PRINCIPALLY ON THE PRODUCTION OF CEREBROSPINAL FLUID

According to the works of Cushing (1914) and Dandy (1929), it has been generally considered that almost all the cerebrospinal fluid (CSF) is formed by the ventricular choroid plexus. Although this concept of CSF production has been modified recently, it is generally accepted that the choroid plexus is the main source of CSF. Concerning the mechanism involved in the CSF production, secretory process within the choroid plexus including active transport of ions is now thought to play an important role.
We studied various factors influencing CSF production in animals using ventriculo-cisternal perfusion technique. As a result, hemodynamic factors within the brain and the choroid plexus, such as changes of blood pressure, CO₂ inhalation, papaverine infusion and carotid ligation, less affected the CSF formation rate, while factors affecting the essential secretory mechanism of the choroid plexus, such as osmotic gradient between blood and CSF and inhibition of carbonic anhydrase or Na-K ATPase, strongly modified the rate of CSF production.
Morphological and functional studies of the choroid plexus in hydrocephalic animals produced by intracisternal kaolin injection have also been carried out. Under such condition, we observed that initially depressed rate of CSF production recovered later to the normal rate within 8 weeks from the time of kaolin injection.

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