J.Jpn. Surg. Soc.. 79(8): 803-806, 1978
Report on the annual meeting
PROBLEMS IN HISTOLOGIC TYPES AS A PROGNOSTIC FACTOR IN RESECTED LUNG CANCER
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National Cancer Center Hospital Keiichi Suemasu |
The 5-year survival rate was 37.1% in 178 cases with squamous cell carcinoma, 23.6% in 203 cases with adenocarcinoma, 33.3% in 39 cases with large cell carcinoma, 5.6% in 18 cases with small cell carcinoma and 41.2% in 34 cases with other histologic types.
Adenocarcinoma revealed rather worse prognosis than squamous cell carcinoma. One of the reason is considered that the central scar which was frequently seen in well differentiated adenocarcinoma was due to the desmoplasia of the tumor and made the central shrinkage of the tumor while tumor cells grew out at the peripheray of the tumor. As a result, the size of the peripheral type of well differentiated adenocarcinoma remained same size for a long time.
Though the size was small, this type of adenocarcinoma showed bad prognosis after surgery because it might have more frequent chance to have metastasis during its long history.
Another reason is that there might be an existence of a subgroup in adenocarcinoma which could have worse prognosis. The subgroup was thought that it might originate from the epithelium of the bronchial gland. We found 16 cases of this type of tumor among 203 adenocarcinomas and the prognosis of this group was worse than that of usual bronchial or bronchiolo-alveolar adenocarcinoma.
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