J.Jpn. Surg. Soc.. 79(8): 746-750, 1978

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Report on the annual meeting

A STUDY ON ADJUVANT CHEMOTHERAPY OF THE BREAST CANCER

Five-year survival rate of 781 cases of breast cancer treated with radical mastectomy was as follows in each clinical stage: stage I 87.2%, stage II 74.8% and stage III 54.3%. In order to estimate the effectiveness of adjuvant chemotherapy of breast cancer, 748 cases out of the above were divided into two groups by strict randomization technics. One of them was the group treated with radical mastectomy alone (group A) and the other was the group treated with the administration of 0.6 or 0.8 mg per kg body weight of mitomycin-C within four postoperative weeks (group B).
Five-year recurrence-free rates of these two groups were statistically compared in nodal status of axillary region as found at the time of surgery. In patients with negative nodes and less than two positive nodes, five-year recurrence-free rate of group B was significantly high comparing with that of group A. On the contrary, in patients with three or more positive nodes, five-year recurrence-free rates of both groups were essentially the same.
The effectiveness of the adjuvant chemotherapy was demonstrated in early stage of breast cancer.

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