J.Jpn. Surg. Soc.. 79(5): 364-381, 1978

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Original article

STUDY ON THE EFFECTIVENESS OF DIFFERENT METHODS OF LOCAL ADMINISTRATION OF ANTI - CANCER DRUGS TO LUNG CANCER PATIENTS .

The effectiveness of local administration of anticancer drugs with different methods on lung cancer patients, have been studied clinically and pathologically. The results showed direct infusion through bronchial artery (BAI) with anti-cancer drugs was effective for hilar typed lung cancer, while the combination of BAI with pulmonary artery infusion (PAI) were much more effective for peripheral cancer. But PAI alone was effective for well differentiated adenocarcinoma of peripheral lesion. For those tumor with endobronchial expansion, bronchofiberscopical injection (BDT) of anti-cancer drug were most effective. Intrathoracic instillation (ITI) of anti-cancer drug were most effective for advanced lung cancer with pleural effusion.
The transformation of peripheral blood lymphocytes in responce to PHA was used to evaluate the effec tiveness of these different methods of applications. Follow-up study with serial PHA-induced transformation test, was a useful parameter to acknowledge the efficacy of surgical therapy, chemotherapy, radiotherapy and immunotherapy. Moreover, its test act as an aid to predict the prognosis and recurrence of the lung cancer.

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