J.Jpn. Surg. Soc.. 79(3): 216-230, 1978

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Original article

EXPERIMENTAL STUDIES ON STUDIES ON LIVER CIRCULATION AND FUNCTION IN SHOCK STATE
Part 1. Influence of Hepatic Blood Flow Change on Liver Function in Shock State

Total hepatic blood flow estimated by the Indocyanine green (ICG) clearance methode has been compared with simultaneous electromagnetic flowmeter measurements in normal dogs and those in unsteady states. These unsteady states include hemorrhagic shock following a single rapid exsanguination (as much as 1% of body weight) and septic shock induced by causing severe periponitis after appendix ligation.
There was good correlation in the normal states, but using the electromagnetic flowmeter technique as the standard, the ICG clearance methode understimated the actual flow by about 30% following hemorhage.
The pictures of septic shock emerged -a low cardiac output state and a high cardiac output state- the latter being associated with better survival. Apart from the differences in cardiac outrut, the ICG methode underestimated the electromagnetic flow value by about 20%.
Possible explanations for these underestimation in shock states were discussed.

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